TOXICITY OF OZONE IN THE RESPIRATORY SYSTEM VIA INHALATION | THERAPEUTIC EFFECT IN THE SPECIFIC FORMS OF MEDICAL OZONE APPLICATION |
Long term exposure 8h etc. with ozone contrations up to 1 ppm* in animals |
Single dose Low concentration, low dose |
Oxidative DYS-stress | Oxidative EU-stress = positive stress |
ROS (reactive oxygen species), LOP (lipid oxidation products), cytokines Increasing infiltration of neutrophils, Activation of macrophages |
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Chronic inflammation
Superoxide and OH-radicals..... Disfunction of anti-oxidants |
Induction of cell metabolism |
Downregulation of anti-oxidants | Regulation of anti-oxidants |
Indications | Underlying effect |
External ulcers and skin lesions Diabetic gangrene | • desinfection • wound cleansing • improved wound healing |
Arterial circulatory disturbances, Angiopathia |
• activation of red blood cell metabolism with improved ..oxygen release • activation of enzymatic antioxidants and radical ..scavengers |
Immune deficiency und immune dysbalance,
Chronic hepatitis (B and C), Complementary oncology, Supportive therapy for rheumatoid arthritis |
• activation of immunocompetent cells and release of
..cytokines such as interferones and interleukins. ..Modulation of the immune system • increase in antioxidant capacity through activation of ..the cellular antioxidants |
Chronic/inflammatory diseases,
Colitis, proctitis, Gonarthrosis Activated arthrosis, Rheumatoid arthritis |
• antiinflammatory effect • activation of antioxidant enzymes and radical scavengers • activation of immunocompetent cells and cartilage cells ..eg with release of TGF-beta |
Chronic pain, myofascial painsyndrome, Triggerpoints, fibromyalgia |
• antiinflammatory effect • activation of antioxidant enzymes and radical scavengers • activation of immunocompetent cells |
Dental medicine • Following tooth extraction • Buccal infections aphthae • Parodontosis |
• desinfection • wound cleansing • improved wound healing |
Contraindications | A glucose-6-phosphate-dehydrognease deficiency in RBCs, favism, acute hemolytic anemia, are also considered as contraindications for ozone (insufficient oxidation protection). Ozone therapy is not indicated in leukemia and in the first 3 months of pregnancy. |
Contraindications | Contraapplications |
Hyperthyreosis if not controlled |
Direct gas injections: intravenous injections strictly prohibited, intraarterial not recommended |
Favism, Glucose-6-phosphate-dehydrogenase deficiency in RBCs |
Hyperbaric ozone auto-hemotherapy infusions
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The first 3 months of pregnancy Acute hemolytic anemia Major autohemotherapy is not indicated in leukemia |
Ozonized infusion solutions if not carefully tested
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